This is a rare growth of mesothelioma cells that is strongly associated with asbestos exposure. Mesothelial cells form the visceral membrane of the lung. Malignant mesothelioma can occur on any mesothelium membrane, such as the peritoneum located inside the abdominal cavity or pericardium which forms the outer part of the heart. The pleural membrane is highly affected, leading to malignant pleural mesothelioma. Subtypes of asbestos strongly associated with malignant mesothelioma are amocyte and crocidolite asbestos.
Causes of Malignant Mesothelioma
Malignant pleural mesothelioma is mainly associated with asbestos exposure, with some suggesting that asbestos inhalation may cause repeated pleural inflammation, interference with mitosis, activation of proto-oncogenes, and free radical production. Other reports suggest association with ionizing radiation for Hodgkin’s lymphoma, such as mantle radiation or the germline mutation of the BRCA1 supplement protein (BAP1). Smoking is not associated with malignant pleural mesothelioma, although smoking and exposure to asbestos significantly increase the risk of lung cancer.
The following occupations are associated with asbestos exposure
Cement manufacturer with asbestos
Manufacturer of auto parts, especially brake linings
The following are not associated with malignant pleural mesothelioma
It is believed that specific genetic makeup or changes make people more likely to get the disease. Research has shown that the loss of a copy of chromosome 22 is more common in patients with malignant pleural mesothelioma.
Other known chromosome disorders that increases risk of mesothelioma lung cancer include deletions in chromosomal arms 3p, 1p, 6q and 9p.